Endocrine Abstracts

Introduction: Pituitary stalk lesions fall into three categories: congenital and developmental (rathke cleft cyst, ectopic neurohypophysis), inflammatory and infectious (hypophysitis, sarcoidosis, tuberculosis), and neoplastic (Langerhans cell histiocytosis, germinoma, metastatic tumors). Herein, we report a case with infundibular lesion presenting with central diabetes insipidus and hypogonadism.Case report: A 27-years old woman was admitted to our clin...

Case: A 28-year old man was admitted to our hospital with complaints of three days of severe headache, diplopia and ptosis of the right eye. He had pituitary macroadenoma and had been on cabergolin 0.25 mg/week for the last six months. At physical examination, he demonstrated ptosis and inability to move the right eye medially. Magnetic resonance imaging showed a 13×12 mm pituitary mass with suprasellar extension and hemorrhage. Visual field analysis was abnormal except t...

Introduction: Radiotherapy to the head and neck area is the standard therapy used for the treatment of nasopharyngeal carcinoma. Hypopituitarism is a well-known late complication of cranial radiotherapy. Although very rarely, it may be observed following radiotherapy to the head and neck area, as well.Case report: A 53-year-old man was referred to our endocrinology department for hyponatremia and low free thyroxine (T4) with normal thyroid- st...

Background: In the literature there are rare cases of patients with known Type 2 Diabetes Mellitus whom are diagnosed as insulinoma. However a synchronous diagnosis with insulinoma and diabetes for a patient presenting with hypoglycemia symptoms is not an expected condition.Case: A 79 years-old female patient was sent to our Endocrinology outpatient clinic because of repeating minor and major hypoglycemia attacks. She had no important finding in her back...

Background: Autoimmune pancreatitis (AIP) is a relatively new entity in which the exocrine pancreas shows lymphocytic infiltration. There are two subtypes of AIP; Type 1 related with Immunoglobulin G4 (IgG4) as the pancreatic manifestation of IgG4-related disease (IgG4-RD), and Type 2 related with granulocytic infiltration. The characteristic features of Type 1 AIP are increased serum IgG4 levels, lymphoplasmacytic sclerosing pancreatitis (infiltration of IgG4+ plasmacytes and...

Background: Acromegaly is a rare neuroendocrine disorder caused by secretion of excessive levels of growth hormone. Somatostatin receptor ligands (SRLs) are first-line medical therapies for patients in whom surgery has failed or is contraindicated. We report a case who had inadequate response to multiple therapies including surgery,radiotherapy,octreotide,lanreotide,cabergoline and pegvisomant.Case: An 44-year-old woman was admitted to our hospital with ...

Objectives: Detection rate of thyroid nodules is increasing with use of new imaging modalities, like 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To avoid unnecessary operations, differentiating between benign and malignant 18F-FDG PET/CT-positive thyroid nodules is essential. Many authorities recommend fine needle aspiration biopsy (FNAB) for exclusion of malignancy in thyroid nodules. Although FNAB is a simple, easily performed proc...

Objective: SAGIT, a new instrument designed for therapeutic decision, is not routinely used yet. While the medical treatment was mostly planned according to disease activity by hormonal evaluation, the therapeutic decision has tried to be standardized with the SAGIT instrument. The aim of this study is to reassess the therapeutic decisions by clinicians in the management of acromegaly according to the SAGIT instrument.Material and Method: This multicente...

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessively inherited disorders that are characterised by inactivating mutations at various steps of adrenal steroidogenic pathways causing defective cortisol biosynthesis. 21-Hydroxylase enzyme deficiency (21-OHd) constitutes more than 95% of all CAH cases.Material & Methods: Medical records of patients with all forms of CAH from 19 adult endocrinology clinics located at six ...